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first_img More From Roadshow Lotus Evija doesn’t look a thing like any other Lotus, and that’s good 2019 Honda Passport: A well-rounded midsize offering 2020 Lotus Evora GT first drive: A reminder to drive Comments Honda OdysseyThe feature-rich Honda Odyssey minivan also retains its number-two slot from last year’s list. While the 2019 model doesn’t see any changes from last, it’s still a darn good choice for families on the go with reconfigurable seats, Wi-Fi and an excellent rear-seat entertainment system. The Cabin Watch video system lets parents keep an eye on their little darlings without turning around in their seats, while Cabin Talk amplifies their voice so no yelling is required.The Odyssey is powered by a 3.5-liter V6 rated for 280 horsepower and 262 pound-feet of torque. Most trims get a nine-speed automatic but the top Touring and Elite trims now use a 10-speed automatic with stop-start technology. The Honda Odyssey is made in Lincoln, Alabama. More From Roadshow Acura MDXMoving up one slot to sixth place on the American Made Index is the non-hybrid variant of the Acura MDX. With its SH-AWD system, the MDX is one of the better handling midsize luxury crossovers, and for 2019 the company gives us the A-Spec treatment with a new front fascia and side skirts, 20-inch wheels, wider exhaust tips, unique gauges, a new steering wheel, carbon fiber trim and various Alcantara interior touches.However, both the standard and A-Spec models get a 3.5-liter V6 engine, rated for 290 horsepower and 267 pound-feet of torque going through a nine-speed automatic transmission. The Acura MDX is made in East Liberty, Ohio.  2020 BMW M340i review: A dash of M makes everything better Now playing: Watch this: 23:22 0 2019 Acura RDX A-Spec: Sharp handling, sharper looks 40 Photos 2019 Honda Ridgeline review: Light duty, heavy punch 81 Photos Share your voice Chevrolet CorvetteMoving up from the 10th-place slot last year is the 2019 Chevrolet Corvette. While we’ve all been ogling the new mid-engine Corvette, it’s easy to forget what a performance bargain the current-generation ‘Vette is. From the base trim to the Grand Sport to the bonkers ZR1, the Corvette is an American icon.My preference is for the Grand Sport, which strikes a perfect balance between everyday drivability and canyon-carving performance. The 6.2-liter V8 puts out 460 horsepower and 465 pound-feet of torque. You can get it with a seven-speed manual or eight-speed automatic transmission, but the kicker is the borrowed chassis and aero parts from the beefier Z06. Like I said, perfect balance. The Corvette is made in Bowling Green, Kentucky. Tags 2019 Chevrolet Corvette Grand Sport loves to hustle 2019 Chevrolet Colorado ZR2 Bison: A tougher off-roader 2019 Jeep Cherokee can handle the rough stuff Post a comment 2019 Honda Ridgeline: The commuter’s pickup truck 52 Photos Honda RidgelineAgain keeping the status quo, the Honda Ridgeline maintains third place on the American Made Index. This crossover-that-looks-like-a-truck provides a better ride than a traditional pickup and gets an awesome lockable trunk right in the floor of the bed. And it doesn’t do the truck stuff too badly, either, as it’s able to carry 1,860 pounds of payload and tow 3,500 pounds.The Ridgeline is powered by a 3.5-liter V6 good for 280 horsepower and 262 pound-feet of torque. That is channeled through a six-speed automatic transmission with available all-wheel drive. It’s built in Lincoln, Alabama. 69 Photos Car Industry 18 Photos 2019 Honda Odyssey offers plenty of room and features for families Enlarge ImageThe Evija is an all-electric hypercar with tremendous power. Charlie Rose/Roadshow Lotus gave us the download on its brand-new Evija hypercar earlier this month, and boy howdy, it’s a stunner. If you’re as stoked as we are to see it in person, you won’t have to wait much longer as Lotus tells us the Evija will make its public debut in just a few weeks.The Evija’s first public appearance will be during Monterey Car Week in August, Lotus officials confirmed to Roadshow on Monday. Look for it to be on display during The Quail: A Motorsports Gathering on Friday, Aug. 16.We could go on and on about the way this car looks; from all angles — and especially the rear — it’s truly stunning. The Evija is about the same size as the current Lotus Evora coupe, and fantastically styled. Perhaps more impressive is what powers the Evija. Lotus still hasn’t released exact specifications, but we’re told total system output from this all-electric hypercar is — ahem — 2,000 horsepower and 1,250 pound-feet of torque. That means the Evija is theoretically good for a 0- to 62-mile-per-hour acceleration time of less than 3 seconds, with a top speed north of 200 mph.Cool as the Evija is, it certainly won’t come cheap. Lotus estimates the car will cost around $2 million, and only 130 will be made. Hubba hubba. We can’t wait to pore over this one in Monterey. 2020 Hyundai Palisade review: Posh enough to make Genesis jealous 10 Photos 26 Photos Jeep CherokeeKeeping its top-of-the-list placement, the Jeep Cherokee is 2019’s most American-made car. Refreshed for 2019, the compact crossover now features more tech, better cargo space and a slightly tweaked look. It’s available in no fewer the nine trims, including the off-road specific Trailhawk and a fancy-pants Trailhawk Elite.For 2019, the Cherokee gets a new 2.0-liter, turbocharged, four-cylinder engine with 270 horsepower and 295 pound-feet of torque, though naturally aspirated I4 and V6 choices are also available. Regardless of engine, a nine-speed automatic transmission gets the power to the pavement — or dirt as the case may be. The Cherokee is made in Belvidere, Illinois. 2019 Chevy Colorado ZR2 Bison: An off-road animal Monterey Car Week 2019 Lotus Honda PilotDropping down to seventh place for 2019 is the Honda Pilot. Like its two-row Passport sibling, the three-row Pilot offers parent-focused technology like Cabin Talk as well as myriad standard driver-assistance features through the Honda Sensing tech suite. Honda’s largest crossover offers up nearly 84 cubic feet of cargo space. Honda’s 3.5-liter V6 engine shows up again, making a serviceable 280 horsepower and 262 pound-feet of torque. Touring and Elite trims get a nine-speed automatic transmission while lower trims have to make do with a six-speed auto. The Honda Pilot is made in Lincoln, Alabama. 12 Photos 68 Photos 3 Tags Share your voice Electric Cars Superluxury Cars 71 Photos Chevrolet ColoradoMaking its debut in the top 10 is the Chevrolet Colorado. Shown here in the tough ZR2 Bison off-road spec, the Chevy Colorado is an excellent truck and one of the two midsize pickups you can get with a diesel engine. Adding to the ZR2’s two-inch lift and front and rear locking differentials, the Bison gets beefier skid plates (trust me, that’s a good thing), steel bumpers and integrated recovery points. Heck, you can even get a snorkel.Base models get a 2.5-liter four-cylinder engine with a six-speed manual transmission, but a more popular choice is the 3.6-liter V6 gas engine with 308 horsepower and 275 pound-feet of torque, mated to an eight-speed automatic transmission. Meanwhile, the 2.8-liter diesel pumps out 186 horsepower and a delicious 369 pound-feet of twist and is mated to a six-speed automatic. The Chevy Colorado is built in Wentzville, Missouri. Acura RDXThe third-generation Acura RDX squeaks into the top ten list with larger proportions, plenty of interior space and better handling than its predecessor. Forward collision warning with collision mitigation braking, adaptive cruise control that works even in low-speed traffic, lane-keeping steering assist and road departure mitigation are all standard across the board. Like its MDX counterpart, the RDX is available with the A-Spec styling package.The RDX sports a 2.0-liter, turbocharged, four-cylinder engine. Output is stated at 273 horsepower and 280 pound-feet of torque, and it’s mated to a 10-speed automatic transmission. The new RDX is built in East Liberty, Ohio. 49 Photos 2019 GMC Sierra Denali review: So close to greatness GMC CanyonIf you’re looking for a slightly fancier version of the Colorado that’s more focused on luxe than dirt, check out the GMC Canyon. The top Denali trim gets standard heated and ventilated front seats as well as a heated steering wheel. Maximum payload capability is 1,665 pounds while max towing is a fairly healthy 7,600 pounds.The Canyon is available with the same 2.5-liter four-cylinder engine, 3.6-liter V6 or 2.8-liter diesel as the Chevrolet Colorado. It’s also built in Wentzville, Missouri. General Motors Chevrolet Honda Jeep Acura Lotus,Enlarge ImageIt’s all in a day’s work for the Jeep Cherokee, the most American-made car in 2019. Jeep With high trade tensions looming and increasing talk of tariffs, more and more consumers are looking to buy American. Cars.com has released its annual American Made Index, showcasing companies that use the most American-sourced parts and labor in their vehicles. The results may surprise you.Cars.com analyzed more than 100 US-built vehicles for five key data points: manufacturing location, parts sourcing, US employment, engine sourcing and transmission sourcing. You might think something like the Ford F-150 would top the list, but it drops from its No. 5 spot for 2018 and out of the top 10 completely. Even the first-place holder, the Jeep Cherokee, is a pretty global product. It’s a Jeep, sure, but that brand is part of Fiat Chrysler Automobiles, an Italian-owned business.Cars.com surveyed 1,000 people and found that half are concerned about automotive import tariffs, with 41% saying they are unsure if tariffs would make them more likely to buy American. Either way, we’re big fans of all the vehicles on this list. These days, buying American doesn’t necessarily mean sticking with a US-based automaker. Honda PassportThe Honda Passport is a new (well, reborn) entry to both the Honda lineup and the American Made Index. This midsize crossover comes to the fray with great driving dynamics and plenty of tech like the standard Honda Sensing suite of active safety features. An available 8-inch touchscreen gets Apple CarPlay and Android Auto as well as a Wi-Fi hotspot.Under the hood is the stalwart 3.5-liter V6 producing 280 horsepower and 262 pound-feet of torque. However unlike the Ridgeline, the Passport sends that power through a nine-speed automatic transmission. Having said that, just like the Ridgeline, this is the only powertrain available. The Honda Passport is built in Lincoln, Alabama. 2019 GMC Canyon: A fancier Colorado Lotus Evija hypercar is an electric rebirth for the British… 2019 Honda Pilot Elite: A smoother, tech-rich crossover SUV 2019 Acura MDX adds new features and an A-Spec modellast_img read more

first_imgBeijing has released a white paper on trade consultations with Washington and accused called the US an unreliable negotiation partner. Investment banker Morgan Stanley says the world could slip into a recession as early as this year if the US-China trade war continues and cautions investors to modify their investment strategy for a prolonged slowdown.Xinhua/twitterThe global economy is probably in recession; with most cyclical indicators showing business, activity is flat or falling. Recessions become obvious only once they are well established given the lagging nature of most economic data.And end-of-cycle recessions are usually impossible to distinguish from mid-cycle slowdowns until well after the slowdown has started.The arrival of a recession is always controversial at the time and usually missed by most forecasters, as the leading business-cycle economist Victor Zarnowitz noted.Policymakers are reluctant to announce a recession for fear of harming consumer and business confidence and worsening the downturn (“Business cycles: theory, history, indicators and forecasting”, Zarnowitz, 1992).But almost all the main economic and industrial indicators that provide a reliable guide to the business cycle confirm the economy has already slowed severely.Global manufacturing surveys, industrial output, new orders, business investment, construction activity, motor vehicle production, and freight volumes are flat or down compared with a year earlier.The most comprehensive numbers show manufacturing production and trade flows were essentially flat in May compared with a year before.More recent data from purchasing surveys and industrial production indicates the slowdown worsened in June and July.By most measures, the global economy is in the midst of the deepest slowdown since 2015, and in many cases since 2009.MARKET INDICATORSFinancial markets and commodity prices show a high probability the economy is in a recession or will be soon.The U.S. Treasury yield curve has been inverted for more than two months and signals the highest probability of recession since April 2007.Major equity indices are flat or down compared with a year ago, despite the sharp reduction in government bond yields and risk-free interest rates since then.Cyclical bellwethers such as Germany’s giant chemicals company BASF and U.S. heavy equipment maker Caterpillar have seen their shares fall sharply over the last year.Oil prices have sunk more than 22% since the end of April, and are down 20% compared with August 2018, despite severe U.S. sanctions on oil exports from Iran and Venezuela.Brent’s six-month calendar spread has collapsed, despite the extension of production restraint by Saudi Arabia and its allies in the OPEC+ group and signs of a slowdown in new well drilling in the United States.Non-oil commodity prices have also been falling or flat since the middle of 2018, as consumption growth has decelerated.POLICY MISTAKESFormer Fed Chairman Ben Bernanke has quipped that expansions do not die of old age, they are murdered – most often because of policy mistakes.In recent decades, most recessions have been brought on by mistakes in some combination of fiscal policy, monetary policy, and financial supervision.In this case, however, the problem has stemmed from trade policy, which has turned sharply protectionist and attempted to remake global supply chains.The resulting economic warfare between the United States and China has heightened business uncertainty and disrupted investment plans in both countries, with spillover effects across Europe and Asia.Policymakers around the world have taken growth for granted, piling on a plethora of tariffs, anti-dumping duties, sanctions and investment restrictions that have finally put the expansion in jeopardy.If a global recession is confirmed, it will be because policymakers were more concerned about other objectives and forgot the need to provide a stable and predictable climate for business.Recession would be a painful reminder and force them to turn their attention back to the economy.(John Kemp is a Reuters columnist)last_img read more

first_img © 2016 Phys.org This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Sorghum. Credit: Public Domain A model of the dhurrin metabolon, summarizing results presented in the paper. Credit:Jean-Etienne Bassard Play 3D model reconstructed from confocal microscope images, using CYP71E1-eGFP as a mean to observe the structures of the Endoplasmic Reticulum. The Endoplasmic Reticulum is where the dhurrin metabolon forms. Only a part of one cell is visible. Credit: Jean-Etienne Bassard PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen (Phys.org)—An international team of researchers has uncovered the mechanism by which the sorghum plant uses the compound dhurrin to ward off pests and herbivores. In their paper published in the journal Science, the team describes their study, their results and the possible impact of their findings on the field of metabolon research. Mehran Dastmalchi and Peter Facchini with the University of Calgary offer a perspective piece on the work done by the team in the same journal issue, calling it a “watershed in metabolon research.” Explore furthercenter_img More information: T. Laursen et al. Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum, Science (2016). DOI: 10.1126/science.aag2347AbstractMetabolic highways may be orchestrated by the assembly of sequential enzymes into protein complexes, or metabolons, to facilitate efficient channeling of intermediates and to prevent undesired metabolic cross-talk while maintaining metabolic flexibility. Here we report the isolation of the dynamic metabolon that catalyzes the formation of the cyanogenic glucoside dhurrin, a defense compound produced in sorghum plants. The metabolon was reconstituted in liposomes, which demonstrated the importance of membrane surface charge and the presence of the glucosyltransferase for metabolic channeling. We used in planta fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy to study functional and structural characteristics of the metabolon. Understanding the regulation of biosynthetic metabolons offers opportunities to optimize synthetic biology approaches for efficient production of high-value products in heterologous hosts. Journal information: Science Prior research has found that the sorghum plant releases chemicals in response to attacks by plant eaters or pests—one such chemical, a substance called hdurrin, has been found to turn into cyanide when hydrolyzed. It is classified as one of a type of complexes known as metabolons, which are temporary complexes formed between enzymes in a metabolic pathway. They maintain their structure due to interactions between cell structures and membrane proteins present in the cytoskeleton. Unfortunately, the nature of metabolons is still not very well understood. In this new effort, the researchers sought to learn more about the general nature of such complexes by studying what happens when sorghum plants are attacked.The team used a recently developed technique that involved the use of styrene maleic acid copolymer and affinity chromatography to obtain lipids along the endoplasmic reticulum which allowed them to isolate dhurrin samples. This allowed them to identify four of the players involved in converting an amino acid to dhurrin. One of them, they found, was a protein that served as an electron donor; two others were proteins that triggered the process, and the fourth was an enzyme that helped the other transactions take place. All four proteins performed in concert, they noted, to convert an amino acid called L-tyrosine to dhurrin. They also found that the membrane itself was actually a critical part of the metabolon character. New forage plant prepares farmers for climate changes Dastmalchi and Facchini note that in addition to offering new insights into how dhurrin is converted to cyanide, the team perhaps more importantly revealed the major role that the endoplasmic reticulum plays in the process and in the workings of metabolons in general. Citation: Characteristics of a metabolon producing the defense compound dhurrin in sorghum revealed (2016, November 18) retrieved 18 August 2019 from https://phys.org/news/2016-11-characteristics-metabolon-defense-compound-dhurrin.htmllast_img read more